The role of cGAS-STING signaling in rheumatoid arthritis: from pathogenesis to therapeutic targets

The role of cGAS-STING signaling in rheumatoid arthritis: from pathogenesis to therapeutic targets

Blog Article

Rheumatoid arthritis (RA) is a systemic autoimmune disease primarily characterized by erosive and symmetric polyarthritis.As a pivotal axis in the regulation of type I interferon (IFN-I) and innate immunity, the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) signaling pathway has been implicated in the pathogenesis of RA.This pathway mainly functions by regulating cell survival, wella color touch 77 45 pyroptosis, migration, and invasion.Therefore, understanding the sources of cell-free DNA and the mechanisms underlying the activation and regulation of cGAS-STING signaling in truvisionhealthftp.com RA offers a promising avenue for targeted therapies.Early detection and interventions targeting the cGAS-STING signaling are important for reducing the medical burden on individuals and healthcare systems.

Herein, we review the existing literature pertaining to the role of cGAS-STING signaling in RA, and discuss current applications and future directions for targeting the cGAS-STING signaling in RA treatments.